Category: T
The active substance present in Thyronorm is 5mg of Thiamazole and the oral solution is an off-white to light yellow opaque liquid which is stored in a 100ml bottle.
Thyronorm 5 mg/ml Oral Solution for cats is a prescription-only medication. This means that before you complete your purchase, you are required to upload a prescription through our online portal.
Once our team has confirmed you've ordered the right medication for your cat, we will send out your order. It's a simple process that means you can buy Thyronorm oral medication online instead of going to your vet every month.
To enhance stabilisation of the hyperthyroid cat, the same feeding and dosing schedule should be used daily. If more than 10 mg per day is required, cats should be monitored carefully.
Following oral dosing with the product in healthy cats, at a dose rate of 5 mg, thiamazole is rapidly and completely absorbed. Elimination of the drug from cat plasma is rapid with a half-life of 4.35 hours. The peak plasma levels occur 1.14 hours after dosing. Cmax is 1.13 µg/ml.
The shelf life of Thyronorm, as packaged for sale, is 2 years, but must be consumed within 6 months of opening.
Thyronorm oral solution is supplied with a 1 ml polyethylene/polypropylene measuring syringe with 0.5 mg increments up to 5 mg.
Do not use in cats:
suffering from systemic diseases such as primary liver disease or diabetes mellitus.
showing signs of autoimmune disease.
with disorders of white blood cells, such as neutropenia and lymphopenia.
with platelet disorders and coagulopathies (particularly thrombocytopenia)
that are pregnant or lactating.
Cats with renal dysfunction should be subject to careful risk/benefit assessment by the clinician.
Cats
For the stabilisation of hyperthyroidism in cats prior to surgical thyroidectomy. For the long term treatment of feline hyperthyroidism.
Please refer to section, ""Use during pregnancy, lactation or lay""
Do not use in case of hypersensitivity to the active substance or to any of the excipients.
In order to enhance stabilisation of the hyperthyroid patient the same feeding and dosing schedule should be used daily.
Special precautions for use in animals
If more than 10 mg per day is required animals should be monitored particularly carefully. Use of the product in cats with renal dysfunction should be subject to careful risk:benefit assessment by the clinician. Due to the effect thiamazole can have on reducing the glomerular filtration rate, the effect of therapy on renal function should be monitored closely as deterioration of an underlying condition may occur. Haematology must be monitored due to risk of leucopenia or haemolytic anaemia.
Any animal that suddenly appears unwell during therapy, particularly if they are febrile, should have a blood sample taken for routine haematology and biochemistry. Neutropenic animals (neutrophil counts <2.5 x 109/l) should be treated with prophylactic bactericidal antibacterial drugs and supportive therapy. Please refer to section, ""Amounts to be administered and administration route"" for monitoring instructions. As thiamazole can cause haemoconcentration, cats should always have access to drinking water.
People with known hypersensitivity (allergy) to thiamazole or one of the excipients should avoid contact with the veterinary medicinal product. If allergic symptoms develop, such as a skin rash, swelling of the face, lips or eyes or difficulty in breathing, you should seek medical attention immediately and show the package leaflet or label to the doctor.
Thiamazole may cause gastrointestinal disturbances, headache, fever, joint pain, pruritus (itching) and pancytopaenia (decrease in blood cells and platelets). Avoid dermal and oral exposure, including hand-to-mouth contact. Do not eat, drink or smoke while handling the product or used litter. Wash hands with soap and water after administration of the product and handling the vomit of or litter used by treated animals. Wash any spillages from skin immediately. Following administration of the product any residual product remaining on the tip of the dosing syringe should be wiped clean with a tissue. The contaminated tissue should be immediately disposed of.
The used syringe should be stored with the product in the original carton. This product may cause eye irritation. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Avoid eye contact including hand to eye contact. In case of accidental eye contact, rinse eyes immediately with clean running water. If irritation develops, seek medical advice. As thiamazole is a suspected human teratogen, women of child-bearing age must wear non-permeable single use gloves when administering the product or handling the litter/vomit of treated cats.
If you are pregnant, think you may be pregnant or are attempting to conceive, you should not administer the product or handle the litter/vomit of treated cats.
Adverse reactions have been reported following long term control of hyperthyroidism. In many cases, signs may be mild and transitory and not a reason for withdrawal of treatment. The more serious effects are mainly reversible when medication is stopped. Adverse reactions are uncommon. The most common clinical side effects that are reported include vomiting, inappetence/anorexia, lethargy, severe pruritus and excoriations of the head and neck, bleeding diathesis and icterus associated with hepatopathy, and haematological abnormalities (eosinophilia, lymphocytosis, neutropenia, lymphopenia, slight leucopenia, agranulocytosis, thrombocytopenia or haemolytic anaemia). These side effects resolve within 7 – 45 days after cessation of thiamazole therapy. Possible immunological side effects include anaemia, with rare side effects including thrombocytopenia and serum anti-nuclear antibodies, and, very rarely, lymphadenopathy can occur. Treatment should be stopped immediately and alternative therapy considered following a suitable period of recovery. Following long-term treatment with thiamazole in rodents, an increased risk of neoplasia in the thyroid gland has been shown to occur, but no evidence is available in cats.
Laboratory studies in rats and mice have shown evidence of teratogenic and embryotoxic effects of thiamazole. In cats, the safety of the veterinary medicinal product has not been established during pregnancy or lactation. Do not use in pregnant or lactating females. From man and rats it is known that the drug can cross the placenta and concentrates in the foetal thyroid gland. There is also a high rate of transfer into breast milk.
Concurrent treatment with phenobarbital may reduce the clinical efficacy of thiamazole. Thiamazole is known to reduce the hepatic oxidation of benzimidazole wormers and may lead to increases in their plasma concentrations when given concurrently. Thiamazole is immunomodulatory, therefore this should be taken into account when considering vaccination programmes."
Royal Mail 2nd Class / Parcel Force 48
UK to UK :Normally arrives in 2-4 business days.
UK to Ireland :Normally arrives in 4-6 business days
UK to EU Countries : Normally arrives in 6-10 working days depending on where the parcel is going
Please note standered delivery is none trackable , none insured , no responsabily for lose or Damage
----------------------------------------------------------------------------------------------------------------
Royal Mail First Class / Parcel Force 24
UK to UK :Normally arrives in 1-2 business days.
UK to Ireland 3-4 business days
UK to EU Countries : Normally arrives in 6-10 working days depending on where the parcel is going
Please note :Trackable , Royal Mail insured up to £50.
--------------------------------------------------------------------------------------------------------
Parcel Force Express AM Guaranteed before Midday.
UK to UK only . UP to 5KG Max Weight
Arrives next day before 12 noon, requires a signature.
Parcel Forcel Terms & Conditions apply
Important: Parcel Force advise that there are some postcodes where an extended delivery time exists, and may affect the date of delivery or the service is not available.
| Category | POM-V |
| Temperature | Ambient |
| MA/VM/EU No: | 02000/4399 |
| Species |
|
| VMD Link | Product Information Database (defra.gov.uk) |
| NOAH Link | https://www.noahcompendium.co.uk/?id=-471326 |
| Dosage | Amounts to be administered and administration route For oral use only. The product should be administered directly into the mouth of the cat. Do not administer in food as efficacy of the product when administered via this route has not been established. For the stabilisation of feline hyperthyroidism prior to surgical thyroidectomy and for the long term treatment of feline hyperthyroidism, the recommended starting dose is 5 mg per day. The total daily dose should be divided into two and administered morning and evening. In order to enhance stabilisation of the hyperthyroid patient the same dosing schedule relative to feeding should be used daily. Haematology, biochemistry and serum total T4 should be assessed before initiating treatment and after 3 weeks, 6 weeks, 10 weeks, 20 weeks, and thereafter every 3 months. At each of the recommended monitoring intervals, the dose should be titrated to effect according to the total T4 and to clinical response to treatment. Standard dose adjustments should be made in increments of 2.5 mg (0.5 ml) and the aim should be to achieve the lowest possible dose rate. In cats that require particularly small dose adjustments, increments of 1.25 mg (0.25 ml) can be used. If total T4 concentration drops below the lower end of the reference interval, and particularly if the cat is showing clinical signs of iatrogenic hypothyroidism (e.g. lethargy, inappetence, weight gain and/or dermatological signs such as alopecia and dry skin), consideration should be given to reducing the daily dosage and/or dosing frequency. If more than 10 mg per day is required animals should be monitored particularly carefully. The dose administered should not exceed 20 mg per day. For long-term treatment of hyperthyroidism, the animal should be treated for life. Overdose (symptoms, emergency procedures, antidotes), if necessary In tolerance studies in young healthy cats, the following dose-related clinical signs occurred at doses of up to 30 mg thiamazole/animal/day: anorexia, vomiting, lethargy, pruritus and haematological and biochemical abnormalities such as neutropenia, lymphopenia, reduced serum potassium and phosphorus levels, increased magnesium and creatinine levels and the occurrence of anti-nuclear antibodies. At a dose of 30 mg thiamazole /day some cats showed signs of haemolytic anaemia and severe clinical deterioration. Some of these signs may also occur in hyperthyroid cats treated at doses of up to 20 mg thiamazole per day. Excessive doses in hyperthyroid cats may result in signs of hypothyroidism. This is however unlikely, as hypothyroidism is usually corrected by negative feedback mechanisms. Please refer to Section, "Adverse reactions". If overdose occurs, stop treatment and give symptomatic and supportive care. |
| Withdrawals |
