Msd Zanil Oral Solution 5Ltr

Target species Cattle and sheep. Indications for use For the treatment and control of chronic fascioliasis in cattle and sheep. It removes practically all flukes (Fasciola spp.) present in the bile ducts of the liver. Contraindications Do not use in cases of hypersensitivity to the active substance. Special warnings for each target species At normal dose levels, oxyclozanide is not active against immature flukes present in liver tissue. Milking cattle, particularly high yielders, may occasionally show a reduction in yield of 5% or more for about 48 hours after handling. The effect of this small loss may be minimised by spreading herd dosing over a period of about a week. Special precautions for use Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy: •Too frequent and repeated use of anthelmintics from the same class, over an extended period of time. •Underdosing, which may be due to underestimation of body weight, misadministration of the product or lack of calibration of the dosing device (if any). Suspected clinical cases of resistance to anthelmintics should be further investigates using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmaceutical class and having a different mode of action should be used. To date no resistance to oxyclozanide has been reported. Use of the product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics. Care should be taken when administering by dosing gun. Due regard must be given to the physical condition of the animals undergoing treatment, particularly those in advanced pregnancy and / or under stress from adverse weather conditions, poor nutrition, penning, handling etc. Operator warnings Do not eat, drink or smoke when using this product. Wash splashes from eyes and skin immediately. Take off any contaminated clothing immediately. User should wear chemical resistant gloves during administration of the product. Wash hands and exposed skin before meals and after work. Adverse reactions At normal oxyclozanide dose levels, cattle may show slight softening of the faeces with the occasional animal showing increased frequency of defecation and transient inappetence. The effects of oxyclozanide overdosage are dullness and some loosening of faeces in sheep and possible diarrhoea, inappetance and loss of weight in cattle. These effects are occasionally enhanced in animals with severe liver damage and/or dehydration at the time of dosing. Use during pregnancy or lactation The product may be given to young, pregnant and lactating animals. Interactions None known.
Vat Rate: 20%