Dolorex 10 mg/ml Solution for Injection 10ml by vet pharmacy online

Category: D

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Target Species: Horse, dog and cat. Indications for use: Butorphanol is intended for use where short (horse and dog) and short to medium (cat) duration analgesia is required. For information on the duration of analgesia that can be expected following treatment, see section ‘Pharmacological particulars’. Horse: For relief of pain associated with colic of gastrointestinal tract origin. For sedation in combination with certain α2-adrenoceptor agonists (see section ‘Amounts to be administered’). Dog: For relief of moderate visceral pain. For sedation in combination with certain α2-adrenoceptor agonists (see section ‘Amounts to be administered’). Cat: For the relief of moderate pain associated with soft tissue surgery. Contra-indications: Do not use in animals with a history of liver or kidney disease. Do not use in cases of hypersensitivity to the active ingredient or to any of the excipients. Butorphanol/detomidine combination: The combination should not be used in horses with a pre-existing cardiac dysrhythmia or bradycardia. The combination will cause a reduction in gastrointestinal motility and consequently should not be used in cases of colic associated with impaction. Special warnings for each target species: In cats, individual response to butorphanol may be variable. In the absence of an adequate analgesic response, an alternative analgesic agent should be used (see section ‘Amounts to be administered’). Increasing of the dose may not increase the intensity or duration of analgesia. Special precautions for use: Butorphanol is a morphinan derivative and therefore possesses opioid activity. Horse: The use of the product at the recommended dose may lead to transient ataxia and/or excitement. Therefore, to prevent injuries in patient and people when treating horses, the location for the treatment should be chosen carefully. Horse, dog, and cat: Due to its antitussive properties, butorphanol may lead to an accumulation of mucous in the respiratory tract. Therefore, in animals with respiratory diseases associated with increased mucous production or in animals that are being treated with expectorants, butorphanol should only be used on the basis of a risk-benefit analysis by the responsible veterinarian. The concomitant use of other central nervous depressants would be expected to potentiate the effects of butorphanol and such drugs should be used with caution. A reduced dose should be used when administering these agents concurrently. The combination of butorphanol and α2-adrenoceptor agonists should be used with caution in animals with cardiovascular disease. The concurrent use of anticholinergic drugs, e.g. atropine should be considered. The safety of the product in young puppies, kittens and foals has not been established. Use of the product in these groups should be on the basis of a risk: benefit analysis by the responsible veterinarian. Operator warnings: Precautions should be taken to avoid accidental injection/self injection. If accidental self-injection occurs, seek medical advice immediately and show the package leaflet or the label to the physician. Do not drive. The effects of butorphanol include sedation, dizziness and confusion. Effects can be reversed with an opioid antagonist such as naloxone. Wash splashes from skin and eyes immediately. Adverse Reactions: Butorphanol may cause the following side effects: Horse, dog, and cat: Sedation may be noted in treated animals. Horse: - Excitatory locomotor effects (pacing) - Ataxia - Reduction in gastrointestinal motility - Depression of the cardiovascular system. Dog: - Depression of the respiratory and cardiovascular system - Anorexia and diarrhoea - Reduction in gastrointestinal motility - Local pain associated with intramuscular injection. Cat: - Mydriasis - Disorientation - Possible irritation at the injection site in case of repeated administrations - Mild agitation - Dysphoria - Pain on injection If respiratory depression occurs, naloxone may be used as an antidote. Use during pregnancy or lactation: The safety of this veterinary medicinal product has not been established in the target species during pregnancy and lactation. The use of the product during pregnancy and lactation is not recommended. Interactions: Butorphanol may be used in combination with other sedatives such as α2-adrenoceptor agonists (e.g. romifidine or detomidine in horses, medetomidine in dogs) where synergistic effects can be expected. Therefore, an appropriate reduction in dose is necessary when used concomitantly with such agent (see section ‘Amounts to be administered’). Because of its antagonist properties at the opiate mu (µ) receptor butorphanol may remove the analgesic effect in animals, which have already received pure opioid mu (µ) agonists (morphine/oxymorphine).

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Category	POM-V
Temperature	Ambient
MA/VM/EU No:	01708/4535
Species	cat dog horse
VMD Link	Product Information Database (defra.gov.uk)
NOAH Link	https://www.noahcompendium.co.uk/?id=-454594
Dosage	Amounts to be administered and administration route: For analgesia: Horse: 0.05 to 0.1 mg/kg, intravenous route, (i.e. 2.5 to 5 ml for 500 kg bw). Dog: 0.2 to 0.4 mg/kg, intravenous route, (i.e. 0.2 to 0.4 ml/10 kg bw). Rapid intravenous injection should be avoided. Butorphanol is intended for use where short duration analgesia is required. For information on the duration of analgesia that can be expected following treatment see ‘Pharmacological particulars’. However, repeat treatments of butorphanol may be administered. The need for, and timing of repeat treatment will be based on clinical response. For cases where longer duration analgesia is likely to be required, an alternative therapeutic agent should be used. Cat: 0.4 mg/kg, subcutaneous route, (i.e. 0.2 ml/5 kg bw). Cats should be weighed to ensure that the correct dose is calculated. An appropriate graduated syringe must be used to allow accurate administration of the required dose volume (e.g. insulin syringe or 1 ml graduated syringe). In the cat, butorphanol is intended for use where short to medium duration analgesia is required. For information on the duration of analgesia that can be expected following treatment see section ‘Pharmacological particulars’. Depending on the clinical response, product administration may be repeated within six hours. In the absence of an adequate analgesic response (see section ‘Special warnings for each target species’), use of an alternative analgesic agent, such as another suitable opioid analgesic and/or a non-steroidal anti-inflammatory drug, should be considered. Any alternative analgesia should take account of the action of butorphanol on opioid receptors, as described under section ‘Interactions’. If repeated administrations are required, use different injection sites. For sedation: Butorphanol can be used in combination with an α2-adrenoceptor agonist (e.g. (me)detomidine or romifidine). Adjustment of the dose will then be necessary according to the following recommendations: Horse: Detomidine: 0.01 – 0.02 mg/kg intravenous route. Butorphanol: 0.01 – 0.02 mg/kg intravenous route. Detomidine should be administered up to 5 min before butorphanol. Romifidine: 0.05 mg/kg intravenous route. Butorphanol: 0.02 mg/kg intravenous route. Romifidine can be administered concurrently or 4 min before butorphanol. Dog: Medetomidine: 0.01 – 0.03 mg/kg intramuscular route. Butorphanol: 0.1 – 0.2 mg/kg intramuscular route. Medetomidine and butorphanol can be administered concurrently. The stopper should not be pierced more than 25 times. Overdose: The main sign of overdose is respiratory depression, which, if severe, can be reversed with an opioid antagonist (e.g. naloxone). Other possible signs of overdose in the horse include restlessness/excitability, muscle tremor, ataxia, hypersalivation, decrease of gastrointestinal motility and seizure. In the cat, the main signs of overdose are incoordination, salivation, and mild convulsions.
Withdrawals	Withdrawal periods: Horse: Meat and offal: zero days. Milk: zero hours.