Product Ref: FOBOF01 Category: B
Boflox is used in cattle for the treatment of respiratory infections caused by strains of Histophilus somni, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida susceptible to marbofloxacin. It can also be used for the treatment of acute mastitis caused by strains of Escherichia coli susceptible to marbofloxacin during the lactation period.
In pigs, Boflox is used for the treatment of Postpartum Dysgalactia Syndrome –PDS-(Metritis Mastitis Agalactia syndrome), caused by bacterial strains susceptible to marbofloxacin.
Boflox 100mg/ml is a prescription-only medication. This means that before you complete your purchase, you are required to upload a prescription through our online portal.
Once our team has confirmed you've ordered the right medication for your cattle and pigs, we will send out your order. It's a simple process that means you can buy Cardalis tablets online instead of going to your vet every month.
The recommended route of administration in cattle is intramuscular, subcutaneous or intravenous. For pigs, the recommendation is that administration is only performed using intramuscular techniques.
In very rare cases administration by the intramuscular route may cause transient local reactions such as pain and swelling at the injection site and inflammatory lesions which may persist for at least 12 days after injection. However, in cattle, subcutaneous route was shown to be better tolerated locally than intramuscular route.
Use during pregnancy, lactation or lay Laboratory studies in rats and rabbits have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. Safety of the veterinary medicinal product at 2 mg/kg body weight has been established in pregnant cows or in sucking calves and piglets when used in cows and sows. Can be used during pregnancy and lactation.
Target species
Cattle and pigs (sows).
Indications for use, specifying the target species
In cattle:
- treatment of respiratory infections caused by strains of Histophilus somni, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida susceptible to marbofloxacin.
- treatment of acute mastitis caused by strains of Escherichia coli susceptible to marbofloxacin during the lactation period.
In pigs:
- treatment of Postpartum Dysgalactia Syndrome –PDS-(Metritis Mastitis Agalactia syndrome), caused by bacterial strains susceptible to marbofloxacin.
Contraindications
Do not use in cases of resistance to other fluoroquinolones (cross resistance).
Do not use in cases of hypersensitivity to the active substance, to any other quinolone or to any of the excipients.
Special warnings for each target species
The efficacy data showed that the product has insufficient efficacy for the treatment of acute forms of mastitis induced by gram-positive bacteria.
Special precautions for use
Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible, fluoroquinolones should only be used based on susceptibility testing.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to (fluoro)quinolones should avoid contact with the veterinary medicinal product. Care should be taken to avoid accidental self-injection as it can induce a slight irritation.
In case of accidental self injection, seek medical advice immediately and show the package leaflet or the label to the physician
In case of contact with skin or eyes, rinse with plenty of water.
Wash hands after use.
Adverse reactions (frequency and seriousness)
In very rare cases, transitory inflammatory lesions can occur at the injection site, without clinical impact, when administered via the intramuscular or subcutaneous route.
In very rare cases. administration by the intramuscular route may cause transient local reactions such as pain and swelling at the injection site and inflammatory lesions which may persist for at least 12 days after injection.
However, in cattle, subcutaneous route was shown to be better tolerated locally than intramuscular route. Therefore, the subcutaneous route is recommended in heavy cattle.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment).
- Common (more than 1 but less than 10 animals in 100 animals).
- Uncommon (more than 1 but less than 10 animals in 1,000 animals).
- Rare (more than 1 but less than 10 animals in 10,000 animals).
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects.
Safety of the veterinary medicinal product at 2 mg/kg body weight has been established in pregnant cows or in sucking calves and piglets when used in cows and sows. Can be used during pregnancy and lactation.
Safety of the veterinary medicinal product at 8 mg/kg body weight has not been established in pregnant cows or in sucking calves when used in cows. Therefore, this dose regimen should be used only according to the benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction
None known.
Royal Mail 2nd Class / Parcel Force 48
UK to UK :Normally arrives in 2-4 business days.
UK to Ireland :Normally arrives in 4-6 business days
UK to EU Countries : Normally arrives in 6-10 working days depending on where the parcel is going
Please note standered delivery is none trackable , none insured , no responsabily for lose or Damage
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Royal Mail First Class / Parcel Force 24
UK to UK :Normally arrives in 1-2 business days.
UK to Ireland 3-4 business days
UK to EU Countries : Normally arrives in 6-10 working days depending on where the parcel is going
Please note :Trackable , Royal Mail insured up to £50.
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| Category | POM-V |
| Temperature | Ambient |
| MA/VM/EU No: | 36547/4002 |
| Species |
|
| VMD Link | Product Information Database (defra.gov.uk) |
| NOAH Link | |
| Dosage | Amounts to be administered and administration route Route of administration: Cattle: Intramuscular, subcutaneous or intravenous. Pigs: Intramuscular. Cattle: Respiratory infections: The recommended dosage is 8 mg marbofloxacin/kg body weight (2 ml veterinary medicinal product/25 kg body weight) in a single injection by the intramuscular route. If the volume to be injected is more than 20 ml, it should be divided between two or more injection sites. In cases of respiratory infections caused by Mycoplasma bovis, the recommended dose is 2 mg marbofloxacin/kg body weight (1 ml veterinary medicinal product/50 kg body weight), in a single daily injection for 3 to 5 consecutive days, by the intramuscular or subcutaneous route. The first injection may be given by the intravenous route. Acute mastitis: - Intramuscular or subcutaneous use: The recommended dosage is 2 mg marbofloxacin/kg body weight (1 ml veterinary medicinal product/50 kg body weight) in a single daily injection, for 3 consecutive days. The first injection may also be given by the intravenous route. Pigs (sows): - Intramuscular use: The recommended dosage is 2 mg marbofloxacin/kg body weight (1 ml veterinary medicinal product/50 kg body weight) in a single daily injection, for 3 consecutive days. To ensure administration of a correct dose, body weight should be determined as accurately as possible, to avoid underdosing. In cattle and pig, the preferred injection site is the neck area. The cap may be safely punctured up to 30 times. The user should choose the most appropriate vial size according to the target species to treat. 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary No signs of overdosage have been observed after administration of 3 times the recommended dose. Signs such as acute neurological disorders may occur when the dose is exceeded. This signs should be treated symptomatically. Do not exceed the recommended dose. |
| Withdrawals | Cattle: Indication Respiratory Mastitis Dosage 2 mg/kg for 3 to 5 days (IV/IM/SC) 8 mg/kg on a single occasion (IM) 2mg/kg for 3 days (IV/IM/SC) Meat and offal 6 days 3 days 6 days Milk 36 hours 72 hours 36 hours Pigs: Meat and offal: 4 days |
