Target species Pre-ruminant calves. Indications for use For the treatment of diarrhoea in pre-ruminant calves associated with infections caused by organisms known to be, or suspected of being, susceptible to the combination of sulfadiazine and neomycin. Contra-indications Do not use in animals with known hypersensitivity to the active ingredient. Do not exceed the recommended dosage or the period of treatment. Do not use local anaesthetics of the procaine group during treatment as they are antagonistic to the sulphonamide component. Do not use in calves with a functional rumen. Do not use in lactating cows. Do not use in foals and horses. Special warnings for each target species Concurrent intravenous fluid therapy should be considered in dehydrated calves. Parenteral antibiotic treatment should be considered if a clinical response is not seen after 48 hours treatment. Special precautions for use Special precautions for use in animals Official, national and regional antimicrobial policies should be taken into account when the product is used. Special precautions to be taken by the person administering the veterinary medicinal product to animals Care should be taken to avoid contact with the skin. Wash hands after use. Sulphonamides may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides may lead to cross reaction with other antibiotics. Allergic reaction to these substances may occasionally be serious. 1. Do not handle this product if you know you are sensitive to sulphonamides. 2. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Adverse reactions Chronic usage of oral neomycin may result in bacterial or fungal superinfections. Use during pregnancy, lactation or lay The product is intended for use in calves only. Do not use in lactating cows. Interactions There is interaction and antagonism between sulphonamides and the Vitamin B Complex. Do not use local anaesthetics of the procaine group during treatment, as they are antagonistic to the sulphonamide component.