Name: Alzane Injection POM 10ml
Brand: Pfizer
SKU: PFALZ01
Price: 69.29 GBP
Availability: InStock

Product Ref: PFALZ01 Category: A

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€ 83.84

Vat Rate: 20%

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Target species Dogs and cats. 4.2 Indications for use, specifying the target species Atipamezole hydrochloride is a selective α2-antagonist and indicated for reversal of the sedative effects of medetomidine and dexmedetomidine in dogs and cats. 4.3 Contraindications Do not use in animals with known hypersensitivity to the active substance or to any of the excipients. Do not use in breeding animals or animals suffering from hepatic, renal or cardiac diseases. See also section 4.7 4.4 Special warnings for each target species None 4.5 Special precautions for use Special precautions for use in animals After administration of the product, the animals should be allowed to rest in a quiet place. During recovery animals should not be left unattended. Make sure the animal has regained a normal swallowing reflex before any food or drink is offered. Due to different dosing recommendations caution should be taken using the product off label in animals other than the target species. If sedatives other than medetomidine or dexmedetomidine are given, it must be kept in mind that the effects of those other agents may persist after the reversal of the effect of the α2-agonist. Atipamezole does not reverse the effect of ketamine, which may cause seizures in dogs and elicit cramps in cats when used alone. Do not administer atipamezole within 30–40 minutes of prior administration of ketamine. Special precautions to be taken by the person administering the veterinary medicinal product to animals Due to the potent pharmacological activity of atipamezole, contact of the product with skin, eyes and mucous membranes should be avoided. In case of accidental contact of the product with skin or eyes rinse abundantly with fresh water. Seek medical attention if irritation persists. Remove contaminated clothes that are in direct contact with the skin. Care should be taken to avoid accidental ingestion or self-injection. In case of accidental oral intake or self-injection, seek medical advice immediately and show the package insert to the physician. Do not drive. The patient should not be left unattended. 4.6. Adverse reactions (frequency and seriousness) A transient hypotensive effect has been observed during the first 10 minutes after the injection of atipamezole hydrochloride. In rare cases hyperactivity, tachycardia, salivation, atypical vocalisation, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination and uncontrolled defecation may occur. In very rare cases recurrence of sedation may occur or the recovery time may not be shortened after administration of atipamezole. In cats, when using a low dose to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be kept in mind. The frequency of adverse reactions is defined using the following convention: - Very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment). - Common (more than 1 but less than 10 animals in 100 animals). - Uncommon (more than 1 but less than 10 animals in 1,000 animals). - Rare (more than 1 but less than 10 animals in 10,000 animals). - Very rare (less than 1 animal in 10,000 animals, including isolated reports). 4.7 Use during pregnancy or lactation. The safety of the product has not been established during pregnancy and lactation. Therefore the use is not recommended during pregnancy and lactation. 4.8. Interactions with other veterinary medicinal products and other forms of interaction Simultaneous administration of atipamezole with other centrally acting medicinal products such as diazepam, acepromazine or opiates is not recommended.
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Category	POM-V
Temperature	Ambient
MA/VM/EU No:	31592/4003
Species	cat dog
VMD Link	Product Information Database (defra.gov.uk)
NOAH Link	https://www.noahcompendium.co.uk/?id=-456432
Dosage	wer of the atipamezole preparation is required. Dosage example dogs: Medetomidine 1.0 mg/ml solution for injection dosage Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage 0.04 ml/kg body weight (bw), corresponding with 40 μg/kg bw 0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw Dexmedetomidine 0.5 mg/ml solution for injection dosage Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage 0.04 ml/kg body weight (bw), corresponding with 20 μg/kg bw 0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw Dexmedetomidine 0.1 mg/ml solution for injection dosage Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage 0.2 ml/kg body weight (bw), corresponding with 20 μg/kg bw 0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw Cats: The atipamezole hydrochloride dose (in µg per kg of bodyweight) is 2.5 times that of the previous dose of medetomidine hydrochloride or five times that of the dose of dexmedetomidine hydrochloride. Due to the fivefold concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the tenfold concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, half the volume of the product to that of the previously administered medetomidine or dexmedetomidine should be given. Due to the 50-fold concentration compared to that preparations containing 0.1 mg dexmedetomidine hydrochloride, a volume 10 times lower of the atipamezole preparation is required. Dosage example cats: Medetomidine 1.0 mg/ml solution for injection dosage Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage 0.08 ml/kg body weight (bw), corresponding with 80 μg/kg bw 0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw Dexmedetomidine 0.5 mg/ml solution for injection dosage Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage 0.08 ml/kg body weight (bw), corresponding with 40 μg/kg bw 0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw Dexmedetomidine 0.1 mg/ml solution for injection dosage Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage 0.4 ml/kg body weight (bw), corresponding with 40 μg/kg bw 0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw The recovery time for dogs and cats is shortened to approximately 5 minutes. The animals become mobile after approximately 10 minutes after administration of the product. 4.10 Overdose (symptoms, emergency procedures, antidotes) if necessary Overdose of atipamezole hydrochloride may result in transient tachycardia and over-alertness (hyperactivity, muscle tremor). If necessary, these signs may be reversed by a medetomidine or dexmedetomidine hydrochloride dose which is lower than usually used clinically. If atipamezole hydrochloride is inadvertently administered to an animal not previously treated with medetomidine or dexmedetomidine hydrochloride, hyperactivity and muscle tremor may occur. These effects may persist for about 15 minutes. Over-alertness in the cat is best handled by minimizing external stimuli.
Withdrawals	Not applicable